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A dose of 300 mg/kg substantially mitigated histopathological damage and DNA fragmentation in lung tissue ( In addition to its direct anticancer mechanisms, PYC attenuates MTX-induced toxicity in vital organs by reducing oxidative damage, inflammation, and histological damage

Because berberine already has glucose-lowering effects similar to some diabetes medications, combining it with GLP-1 drugs may amplify those effects

Research has also connected GLP-1 drugs, specifically liraglutide, to certain gallbladder issues