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These reflect either elevated cardiometabolic risk (prediabetes) or established cardiovascular disease (prior heart attack, prior stroke, symptomatic PAD)

Statistical analyses Statistical analysis was performed with the STATISTICA 13.0 software (StatSoft, Poland)

(2018) 23:297301.e4

Some researchers use weekly dosing most of the time and switch to split dosing during periods when side effects are particularly bothersome, such as during dose escalation

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