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An attempt to identify Nrf2 target genes in cancer cells revealed that Nrf2 directly activates the genes whose products are involved in the pentose phosphate pathway and nicotinamide adenine dinucleotide phosphate (NADPH) production, such as glucose-6-phosphate dehydrogenase (G6PD), phosphogluconate dehydrogenase (PGD), transketolase (TKT) and transaldolase 1 (TALDO1), and malic enzyme 1 (ME1

Furthermore, activated Akt stimulates specific phosphorylation of FoxO proteins in the nucleus leading to their extrusion into the cytoplasm [5]

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The 3D pigmented skin model provided valuable insights into the translational potential of DEC by recapitulating the complex architecture of the epidermis and the functional interactions between melanocytes and keratinocytes, thereby offering a more physiologically relevant system 25

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Negative Feedback Regulation: Sermorelin-induced growth hormone release is subject to negative feedback regulation involving somatostatin, a neurohormone that inhibits further hGH secretion