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doi:10.1016/j.phymed.2014.12.010 DISCLAIMER: These statements have not been approved by the Food and Drug Administration

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Additionally, recent studies indicate that semaglutide regulates myocardial energy metabolism via the Creb5/NR4a1 axis within the PI3K-AKT pathway, reducing NR4a1 expression and its mitochondrial translocation, thereby improving cardiac remodeling [220]

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