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Starting doses typically begin at 3mg once daily for 30 days as a starter dose for tolerability, not for glycaemic control

Moreover, C- peptide/insulin ratios are poor estimates of hepatic insulin clearance due to varying kinetics of the C peptide compared to insulin (72)

Notably, the pattern of change in SBP on placebo across the groups aligned with that for semaglutide, 1.79 mmHg for the HTN group and 12.57 mmHg for the HTN140 group

Tirzepatide is administered once weekly on the same day each week and can be taken any time of day, with or without food