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Semaglutide has randomized trial evidence in nonalcoholic steatohepatitis demonstrating improvement in key disease activity outcomes. Tirzepatide also has randomized trial evidence in metabolic dysfunctionassociated steatohepatitis (MASH) with liver fibrosis, supporting improvements in steatohepatitis-related endpoints. Clinical takeaway: GLP-1 and GLP-1/GIP therapies can reduce liver fat and liver injury activity in metabolic liver disease settings., 3) They Improve Cardiometabolic Risk Factors That Overlap With Vascular Inflammation Vascular inflammation is an umbrella term

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CBS = cystathionine -synthase

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