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This pathway involves activation of phosphatidylinositol phospholipase C (PI-PLC), phosphatidylinositol 4,5-bisphosphate (PIP 2 ) and inositol trisphosphate (IP 3 ), ultimately resulting in mobilization of intracellular Ca 2+ stores (Camia et al., 2007)

4C and Figure S5)

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12), which may be associated with the greater dynamics within the bundle, given the bound peptide bridges these two domains and stabilises their motions relative to one another

O GHK-Cu , tambm conhecido como peptdeo de cobre , um ativo amplamente estudado na dermatologia por sua atuao na regenerao da pele , cicatrizao e reparao drmica