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In some instances, upon administration of a controlled release auris formulation or composition described herein (e.g., a formulation comprising a therapeutic agent), drug concentrations relative to the binding constants of one or more otic receptors are relevant in determining a biologically meaningful PK profile or the minimum concentration of an active agent required for a therapeutic effect

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The first suggestion of NOS-independent NO generation from inorganic nitrite and in vitro demonstration of its role in gastric host defence

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Doses above 200-300 mg/day are typically reserved for supervised therapeutic use