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Neuroscience 26(277):747754 Paudel YN, Angelopoulou E, Piperi C, Shaikh MF, Othman I (2020) Emerging neuroprotective effect of metformin in Parkinsons disease: a molecular crosstalk
Recombinant jr PPO1-wt shows higher affinity and activity towards the monophenolic substrate tyramine ( k cat = 24.7 s 1 and K m = 0.451 mM) in comparison to L -tyrosine ( k cat = 6.0 s 1 and K m = 1.42 mM, Table 2)
doi: 10.1007/s12032-025-02901-3 86 TalalayPFaheyJWHealyZRWehageSLBenedictALMinCet al
this effect will counteract the excessive ROS released by MTX, preserving the level of both enzymatic and non-enzymatic antioxidants.[] Furthermore, pomegranate causes Nrf2 translocation from cytosol to the nucleus, which may cause cytoprotective events and increase hepatic GSH and SOD levels as part of this event.[] As a result of the positive pomegranate effect on GSH and SOD and enhancement of antioxidant capability in the liver tissue, pomegranate will ameliorate the oxidative stress caused by MTX and a reduction of ROS induce lipid peroxidation, which was reflected by the significantly lower level of MDA in the liver tissue compared to the control group
Although subcutaneous injections are generally painless, they can cause some patients to feel slight discomfort as subcutaneous tissue contains pain receptors.
