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Small-molecule inhibitors such as MCC950 have shown efficacy in inhibiting NLRP3 activation and ameliorating liver injury in experimental models of APAP overdose

In CD, the microbiota triggers the Th1 response, leading to the release of IFN- and TNF-, ultimately resulting in damage to the mucosal barrier (76)

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Orphanet J Rare Dis 2012 Sep 18;7:68(6 pp)

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