The PCR amplification primers and siRNA sequences were provided in Supplementary Table S1
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ZarkovicNZarkovicKMilkovicLAndrisicLBorovicSWaegGet alRevealing 4-Hydroxynonenal-Histidine adducts as qualitative and quantitative biomarker of oxidative stress, lipid peroxidation and oxidative homeostasis
You may be a candidate if: You have documented excess visceral fat with imaging or waist circumference criteria You have features of metabolic syndrome elevated triglycerides, insulin resistance, impaired fasting glucose You have evidence of GH-axis insufficiency or age-related GH decline (low IGF-1) You have not achieved adequate visceral fat reduction through lifestyle modification alone You are being treated for HIV-associated lipodystrophy (the FDA-approved indication) You are not pregnant and do not have active malignancy both are absolute contraindications Lab workup typically includes: Fasting IGF-1 level Fasting glucose and insulin (HOMA-IR for insulin resistance) Full lipid panel Hemoglobin A1c Liver function tests Baseline CT or MRI for VAT quantification (in research settings) Meto's Comprehensive Metabolic Panel covers the core biomarkers fasting glucose, fasting insulin, lipid panel, liver markers, and inflammation markers giving your provider the baseline data needed to evaluate your candidacy accurately
