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Since muscles contribute to energy expenditure at more than twice the rate of fat tissue, the reduction in muscle and other lean mass accompanying fat loss results in lower energy expenditure after weight reduction

This drives endothelial cell proliferation and migration, creating new vasculature in damaged tissue

[10] [11] Additional cautions include: risk of hypoglycaemia when combined with insulin or sulfonylureas

J Toxicol Environ Health Part B 13(5):385

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MZB have the potential to self-renew 18 and are activated more quickly than FoB 7,8 , properties consistent with a requirement for glycolytic reprogramming in activated B cells 101