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BMJ 385 , e078483 (2024)

10.1172/JCI77632 87 OnishiM.YamanoK.SatoM.MatsudaN.OkamotoK

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Placebo (FOURIER trial, N=27,564) Monitoring recommended / fasting lipid panel every 4 to 12 weeks after initiation Prescriber disclosure / always required for any new supplement How Repatha (Evolocumab) Works and Why Metabolism Matters Evolocumab is a fully human IgG2 monoclonal antibody that binds proprotein convertase subtilisin/kexin type 9 (PCSK9), blocking PCSK9 from degrading LDL receptors on hepatocytes

This stepwise titration allows the body to adapt to the medication and reduces the incidence and severity of adverse effects