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It remains to be elucidated whether the process of aging is accelerating only on the skin while GLP-1RA is delaying the systemic aging, and if so, which exact pathophysiological mechanisms are hidden behind this complication

This dual action helps regulate blood glucose levels with a low risk of hypoglycaemia when used alone (though this risk increases when combined with insulin or sulphonylureas)

This matches official guidelines (for example, Hospiras package insert)

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for background on sitagliptin combinations, see Janumet XR as an example of fixed-dose pairing

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