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As a precaution, patients with severe kidney disease may be advised to use alternative B12 forms

As with any therapy, long-term studies are still limited, so ongoing observation and clinical research will further define its safety profile

Studies indicate that individuals with lower B12 levels are more likely to be obese[2], even after accounting for factors like diet, lifestyle and medication use

It plays an important role in nutrient metabolism, antioxidant defense, and controlling nitroxidative stress

Unfortunately, this trial did not pass Phase I with five of the seven enrolled patients experiencing serious adverse effects, including supraventricular tachycardia, convulsion, and pulmonary embolism

Focus (Am Psychiatr Publ)