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Computational methodologies, such as network pharmacogenomics, pathway enrichment analyses, and the reconstruction of pathway-pathway comorbidity networks, have provided valuable insights into the pathological mechanisms underlying diseases, including comorbidities and the influence of environmental factors such as viral and bacterial infections in disease development and/or progression 19,20,21,22,23,24

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IL-6 secretion was measured after the stimulation of k , CT26 and l , Raw264.7 cell lines with Lactobacillus spp., Bifidobacterium spp ., or Akk (ATCC BAA-835) (cell to bacteria: 1:10)