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In most cases, the designation of Option reflects the Panel's judgment that uncertainty existed for the balance between benefits and risks/burdens for a particular treatment

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The OGDHC reaction product succinyl-CoA provides for the only mitochondrial phosphorylation reaction of ADP to ATP, at the substrate-level, i.e., phosphorylation beyond mitochondrial respiratory chain

Hepatic fibrosis is the main determinant of MASLD progression

Tuttle KR, Agarwal R, Alpers CE, Bakris GL, Brosius FC, Kolkhof P, Uribarri J