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Again, this could be completely prevented by DPP-4 inhibition with valine pyrrolidide, confirming that cleavage by DPP-4 was the key initial step in GLP-1 degradation, and that other enzymatic pathways played a limited role (25)

Since the data obtained from KID mice showed levels of bioactivity similar to the control group, the research team hypothesized that the difference in recorded results stemmed from the RIA kit only recording fragments of IGF-1 DES that were bound to IGF-1 binding proteins with a low affinity [3]

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