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reported reductions of uncertain significance, these studies did not distinguish between NAFLD stages [100,101]

Glucagon receptor (GCGR) agonism increases hepatic energy expenditure through glycogenolysis and gluconeogenesis upregulation, and promotes thermogenesis in adipose tissue

Therefore, thorough investigation is necessary to evaluate the risks and benefits of PA in different therapeutic contexts

The pro-inflammatory cells and cytokines also interact with obesity, steroid hormones imbalance and IR, leading to increased metabolic imbalance and reproductive-endocrine dysfunction in PCOS patients

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