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For example, cognitive dysfunction (doggy dementia) occurs in 28% of dogs aged 11-12 and up to 68% in dogs aged 15 years or over 1 , and heart disease is another condition that increases in prevalence as our dogs age

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and (iii) eNOS-mediated arginine catabolism leading to upregulation of wingless/integrated (Wnt) pathway and accelerated progression of colorectal cancer [92]

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Cataract development is mainly attributed to oxidative stress, which damages epithelial lens proteins and lipids, resulting in clouding or opacification of the normally transparent lens and altering its refractive index

Metastatic or primary lung tumours were shown to rely on enhanced expression of NFS1 to maintain the supply of FeS clusters as co-factors of multiple essential proteins and enzymes in the cell that are exposed to (damaging) high oxygen concentrations