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[PMC free article: PMC209498] [PubMed: 11602619] 33

Additionally, GLP-1 RAs have been demonstrated to activate AP-1, which regulates the expression of apoptotic genes, and to phosphorylate Bad, a pro-apoptotic factor, thereby reducing apoptosis [47] (Fig

*Correspondence: Rafael de la Torre, Neurosciences Research Program, Human Pharmacology and Clinical Neurosciences Research Group, IMIM-Hospital del Mar Medical Research Institute, PRBB Building, Office 221.03, Doctor Aiguader 88, 1st floor, 08003 Barcelona, Spain

(57), but it took almost 40 years before it was realized that this was likely due to the disruption of the liver-cell axis

This drug may cause side effects, including but not limited to dizziness, drowsiness, insomnia, dry mouth, sweating, decreased appetite