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We observe a hydrophobic extracellular gate directly above the substrate-binding site, similar to that seen in OCT1, where residues of gating helices TM1 and TM7 pack together in both the occluded and inward conformations (e.g

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doi: 10.1016/j.mcn.2017.06.004

PKA also affects integrin-dependent migration in a variety of cells (119) and PKA and its phosphorylated substrates are enriched in cellular protrusions (111, 120)