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In Japan, where over 70% of individuals with diabetes are aged 65 or older and often exhibit a non-obese phenotype with impaired insulin secretion, dipeptidyl peptidase-4 inhibitors remain a cornerstone therapy due to their ability to enhance insulin secretion without increasing hypoglycemia risk

Box breathing involves inhaling for four seconds, holding for four seconds, exhaling for four seconds, and holding empty for four seconds

Methods An extensive and systematic literature search was conducted over a 3-month period, from April 2024 to June 2024

Chua GS, Pham J, Anpalahan M

Across the six published trials, the most common adverse events were headache, mild gastrointestinal effects (diarrhea, flatulence, nausea), nasopharyngitis, fatigue, dizziness, and mild injection-site reactions