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However, their pharmacological effects alter eating behaviour, gastrointestinal dynamics and weight loss patterns in ways that may indirectly influence nutritional status

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Angiology 26 , 474487 (1975)

But for a larger group the patients who have tried every diet, who exercise faithfully, who do everything right and still cant move the needle, that model is more than just incomplete

[DOI] [PubMed] [Google Scholar] Young AJ, Lowe GM

Persistence remains mixed: a 2024 real-world study found 32% on therapy at 1 year among non-diabetic users, and according to Prime Therapeutics, only 1 in 12 remain at 3 years