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These effects can all change how the body functions

In short, the drugs trigger insulin release, reduce glucose production in your liver and make a person feel full

Journal of Clinical Investigation, 135(21)

And unless you change not only how much but also what you eat, you will never be able to get off of these drugs

The final mathematical model, using Monte Carlo simulations (as implemented in the NONMEM software) and the final estimated parameters, allowed us to simulate, with a high level of accuracy, plasma drug levels as a function of dose, even for doses not directly tested