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Mitochondria may mediate prenatal environmental influences in autism spectrum disorder

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A fourth factor must now be built into the equation, namely, gene mutations that might favour the cytoplasmic presence of trypsin (97): the enzyme, as also chymotrysin, is readily inhibited by GSH via SH-SS exchange (24) should it break loose of constraint by SPINK1 (serine protease inhibitor Kazal type 1) (118), but less GSH is then available for control of electrophilic / oxidative stress and other vital roles (24, 30, 162)

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Chatterjee R, Chowdhury AR, Mukherjee D, Chakravortty D (2023) From Eberthella typhi to Salmonella Typhi: the fascinating journey of the virulence and pathogenicity of Salmonella Typhi

Ubiquitination is a hierarchical cascade of enzymatic reactions catalyzed by three enzymes ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin-ligating (E3) enzymes ( Figure 2 2.2 Non-Keap1-mediated regulation In addition to the Keap1 signaling pathway, other signaling pathways can also affect the transcription of Nrf2 ( Figure 2 )