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L-arginine, an amino acid that promotes nitric oxide synthesis and improves blood flow

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Clinical decision-making has become further complicated by the emerging significance of TDLNs for tumor antigen presentation (30), T cell priming (3133), immunotherapy response (3436), cancer vaccines (3739) and CAR-T therapy (4042), underscoring the need to consider the implications of LN removal on immunotherapy

However, significant controversy exists regarding the relative contributions of these parallel pathways in different cellular contexts