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The vial may still look clear and normal, but the compound is partially inactive

In 1999, the European Respiratory Society (ERS) [2] defined therapy-resistant asthma as persistent asthma symptoms or evidence of obstruction despite 6 months of appropriate guideline-based asthma management

Topiramate has been shown to be an effective and well-tolerated prophylactic medication for the treatment of migraine (Afshari et al., 2012), but the mechanism has not yet been clarified

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whether or not the companies drug warnings are adequate as a matter of law