As far as the intracellular Cu(I) discharge pathways are concerned, Cys containing small peptides, such as GSH, or the antioxidant peptide Atox1 may contribute to Cu(I) release from the carrier
Glutathione protects cells from the oxidative stress that iron can create
Furthermore, we provide first data that the GSH level in human neurons may be mediated by NMDAR activation since the protective effect of enhanced network activity could be blocked with an NMDAR antagonist APV, consistent with the previous report (Fig
Front Pharmacol 13:1003812 Yamamoto Y, Gaynor RB (2001) Therapeutic potential of inhibition of the NF-B pathway in the treatment of inflammation and cancer
Quality matters
Glutathione is a tripeptide made up of three components, which are glycine, cysteine, and glutamic acid