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Biofilm-resident bacteria exhibit a reduced metabolism and an altered proteome compared to their planktonic counterparts, features that contribute to their reduced susceptibility to immune effectors and commonly used antibiotic treatments (Novotny et al., 2019)

A three-pumps-a-day regimen gets you closer to a 30-day use life, but then you still have a three-day surplus

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PMID: 14630268

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To do so, Se-species have to cross the bloodbrain barrier (BBB) and/or bloodcerebrospinal fluid barrier (BCB) of the choroid plexus