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The musculoskeletal side effects include muscle pain, muscle weakness, cramps and swelling in extremities including hands, arms, ankles, feet and/or lower legs

RPE cells: Diverse receptor expression including growth factor receptors (EGFR, FGFR, PDGFR), cytokine receptors, integrin adhesion receptors

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It must be remembered that desensitisation is not always successful and the state of desensitisation is temporary

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