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While enrollment in the dose-finding portion had begun, the CRLs indicate that the confirmatory portions of these trials should be underway, Regeneron stated

The 2024 EASL-EASD-EASO guidelines emphasize that MASLD is closely linked to the main cardiometabolic risk factors (especially type 2 diabetes and obesity) and that the risk of complications increases as these factors accumulate

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Traditional equations for cardiovascular risk Risk stratification requires a comprehensive evaluation that integrates traditional CMRFs with disease-specific markers [Figure 1]

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[3] [12] Testing for B12 status should be based on symptoms or risk factors rather than routine screening, with healthcare professionals assessing individuals who may be at higher risk of deficiency