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Those thresholds match what we already use for other GLP-1 medications

The no-effect doses for embryofetal developmental toxicity in mice, rats, and rabbits (75, 6.25, and 30 mg/kg, respectively) are similar to (mice and rabbits) or less than (rats) the human dose of 400 mg/day on a body surface area (mg/m 2) basis

However, pharmacological GIP receptor agonism at high doses appears to produce weight loss rather than gain, possibly through desensitization of adipocyte GIP signaling or through central appetite effects

Supplementary material The Supplementary material for this article can be found online at: References 1 AbikoY.MiuraT.PhucB

"Risks include bruising, swelling, pain, fractures and injury to delicate facial structures," Maercks said