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In the non-classical pathway, lipopolysaccharide (LPS) directly activates caspase-4/5 in humans or caspase-11 in mice, bypassing inflammasomes (Sahoo et al., 2023)

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J Anim Physiol Anim Nutr (Berl)

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The cause of MIS-C is not yet fully understood its a question thats being actively investigated, here at Boston Childrens and elsewhere

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