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Johns wort, a nutritional supplement, may interact with it, raising the risk of serotonin syndrome

Enhanced bioavailability and immune benefits of liposome-encapsulated vitamin C: a combination of the effects of ascorbic acid and phospholipid membranes

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Ben-Zvi A, Lacoste B, Kur E, Andreone BJ, Mayshar Y, Yan H, et al

Glutathione stays steady in its reduced form because of vitamin C

Excessive long-term use of B6, particularly at doses above 200 milligrams daily sustained over months, can cause sensory neuropathy