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MOTS-c restores their ability to run on fat, and NAD+ supplies the cofactor combustion spends

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Whereas general obesity and central adiposity, in particular, are the primary factors responsible for the development of insulin resistance, postprandial increases in insulin secretion causes a further expansion of the adipose tissue mass, which further worsens insulin resistance

doi: 10.1126/scitranslmed.aad7151 151 MoranEMHeydrichRNgCTSaberTPMcCormickJSieperJet al

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