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Antioxidant 9(8):681

Ice crystal formation during freezing can physically disrupt peptide structure, while thawing allows water to access reactive sites

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Peer review Peer review information Nature Reviews Urology thanks Zhendong Zhu and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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"This study does present some compelling evidence suggesting that supplementation with B12 can cause or exacerbate acne in a subset of individuals," said Dr