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Symptoms include severe persistent abdominal pain radiating to the back, nausea, vomiting, and elevated pancreatic enzymes

More recent work has shown that MOTS-C translocates to the nucleus under metabolic stress, where it regulates adaptive nuclear gene expression and influences whole-body energy metabolism (Kim et al., 2018

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Lipolysis Enhancement and Lipogenesis Inhibition In obese Zucker rats, daily oral administration of AOD9604 significantly increased lipolytic activity in adipose tissue compared to controls, establishing direct adipocyte-level lipolysis stimulation as a key mechanism of action in pre-clinical models

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