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Similarly, post hoc analyses of Harmony Outcomes and DECLARETIMI 58 suggested preserved benefit with concomitant therapy, but these studies were not powered to establish additive efficacy of the combination [26, 27]

To avoid metHb accumulation, reducing pathways mediated by cytochrome b5 or flavin coupled with NADH- or NADPH-dependent metHb reductases (MHbR), respectively, keep the level of metHb in erythrocytes at less than 1% of the total Hb under normal conditions (48)

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Science 296 , 13131316 (2002)

By virtue of this specific mechanism, we further successfully developed a strategy of target-blocking this binding to protect the ovary from NRTP-induced damage