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Genetic approaches to manipulate hepatic oxalate metabolism included generation of Agxt -/- mice using CRIPSR/Cas9 and hepatocyte-specific overexpression of AGXT using AAV8-TBG-AGXT during diet-induced MASH

Resveratrol ameliorates lipid droplet accumulation in liver through a SIRT1/ ATF6-dependent mechanism

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What began as an unexpected observation and side effect of some medications converged with decades of addiction neuroscience: GLP-1 receptor agonist medications like Ozempic apparently reduce alcohol craving, drinking intensity, and relapses

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