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Induction of cardiac specific leptin receptor (LepR) deficiency in lean adult mice also caused severe cardiac dysfunction [15, 16]
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As a consequence, more recent efforts have focused on the development of second- and third-generation CB1 receptor antagonists that are peripherally restricted and still produce the metabolic benefits of rimonabant in rodent models of obesity and diabetes without the central psychiatric side effects (for review, see [98])
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