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Disruption of Sel1L-HRD1 activity leads to tissue-specific ER stress and systemic metabolic imbalance, underscoring its pivotal role in maintaining whole-body homeostasis

Indole-3-acetic acid (IAA), produced by gut microbiota, alleviates fibrosis by suppressing PI3K/AKT/mTOR signaling, enhancing autophagy, and reducing fibroblast activation and epithelial senescence [114]

Clones were screened by Western blot using anti-hCystatin C antibody MAB1196 (R&D, Minneapolis, MN)

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Cis-DDPs well-known nephrotoxicity, indeed, has been proved to be related to his GSH-conjugated compounds that, being metabolized to cysteine S-conjugate by cysteine S-conjugate -lyase activity (highly expressed in renal cells), is mainly responsible for proximal tubule cell damage [114]