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The failure to achieve normal PRL or lack of relevant tumor shrinkage ( 30% in maximum diameter or 50% in volume) when treated with standard DA doses (10 mg per day of BRC or 2 mg per day of CAB) at least 6 months is defined as DA resistance (200)

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Authors Rexford S

Thus, once glucose has been phosphorylated, any potential hindrances until the aldolase step can be bypassed through the pentose phosphate pathway by provision of glyceraldehyde-3-phosphate

Liraglutide also restored neuronal insulin sensitivity in hyperinsulinemic conditions and reduced the A formation and tau hyperphosphorylation in neuronal cells (215)

It means the relationship between concentration and results isn't linear