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78 These DAMPs act as danger signals that activate innate immune receptors, including pattern recognition receptors

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For instance, in study (Teixeira and Rumjanek, 2014), in which the activating effect of CTS was observed, human monocytes were treated with 100 nM of ouabain in vitro , whereas the inhibitory effect was described in vivo on mice with ouabain concentrations reaching 0.56 mg/kg (Jacob et al., 2013), when the maximum concentration in the blood is in the micromolar range

Cancer cell membrane-camouflaged nanorods with endoplasmic reticulum targeting for improved antitumor therapy

Zhongguo Shi Yan Xue Ye Xue Za Zhi 31 , 197202 (2023)

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