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In consultation with a prescriber, temporary dose reduction can be considered for severe symptoms, with subsequent re-escalation once gastrointestinal function stabilises

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Variants occurring below this threshold are sometimes called variants , though this term is also used broadly to describe any DNA difference, regardless of frequency or effect

370,371,372 Thus, insulin signaling likely also carries important and diverse roles in brain functioning and AD pathogenesis

This constitutes a significant clinical difference, exempting it from the essentially a copy restriction

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