Disclosure Giorgio Cruccu received a research grant, consulting fees and payments for lectures from Sigma-Tau of Alfasigma Group, and consulting fees from Angelini, Biogen, and Mundipharma
SPAE treatment also modulated upstream regulators Keap1 and AMPK, supporting activation of the Nrf2 and PPAR- pathways
Mild effects like bruising at the IV site are common, but serious complications such as infection or electrolyte imbalance are rare when protocols are followed
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