glutathione ovarian cancer Carbon monoxide sensitizes cisplatin-resistant cell lines toward cisplatin via attenuation of levels of and nuclear metallothionein Unbiased assessment of APR-246 responsive

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Inhibition of glutathione metabolism by BSO decreased the ESCC tumor burden To investigate whether glutathione metabolism contributed to the progression of ESCC development, we treated mice bearing ESCC 20 weeks after initial carcinogen treatment with buthionine sulfoximine (BSO), a commonly used chemical inhibitor of -glutamylcysteine synthetase (-GCS) that decreases tissue glutathione concentrations (Figure 3a)

2.Supporting Immune Balance: Glutathione is crucial for the normal function of the immune system

Additional information Responsible Editor: Gangrong Shi Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations

It induces apoptosis in malignant cells by upregulating p27kip1 and Caspase-3, acting as a "smart" molecule that supports healthy cells while targeting damaged ones