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The serum level of LC was measured by enzyme-linked immunosorbent assay (ELISA) using commercially available kits (Cusabio, Wuhan, China) according to the instructions made available from the suppliers
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[35] This high requirement for NAD + results from the constant consumption of the coenzyme in reactions such as posttranslational modifications, since the cycling of NAD + between oxidized and reduced forms in redox reactions does not change the overall levels of the coenzyme
Still, with a long-half-life drug like amlodipine, even mild CYP3A4 inhibition adds up over time because each dose clears more slowly than the last
This tip holds true when youre not on a medication as well