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The physiological role of native GLP-1 includes stimulating insulin secretion, suppressing glucagon release, and slowing gastric emptyingall mechanisms that contribute to glucose homeostasis

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PINK1 mutations in humans lead to mitochondrial defects and respiratory chain abnormalities (Hoepken et al., 2007

doi: 10.1111/febs.17333 151 Kullak-UblickGAStiegerBMeierPJ

ESWT is most effective when guided by high-resolution ultrasound imaging

Other important safety considerations include risk of hypoglycaemia when combined with insulin or sulfonylureas, potential gallbladder disease, and the need for monitoring in patients with pre-existing diabetic retinopathy