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Compared with oral semaglutide, subcutaneous tirzepatide is cost-effective, with an ICER of $34,212 per QALY gained at 68 weeks
3A, Supplemental Table 2)
A key differential side effect for Retatrutide is a transient, dose-dependent increase in heart rate observed in the clinical trials, which necessitates careful cardiac screening and monitoring by a supervising physician
Zepbound is approved by the Food and Drug Administration for weight loss and chronic weight management in people with obesity or people who are overweight and have at least one weight-related health condition, to be used along with a reduced-calorie diet and physical activity
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